Gene information
Official symbol HMGB1
Official full name high mobility group box 1
Gene type protein-coding gene
Chromosome13q12.3
Alias symbolHMG3; SBP-1; DKFZp686A04236
Previous symbolHMG1
Gene familyCanonical high mobility group
Resources
Entrez Gene 3146
HGNC HGNC:4983
Ensembl ENSG00000189403
Vega OTTHUMG00000016670
UCSC uc058wdx.1
GO terms: 217 records
GO Description Category LogP Number of genes Detail
GO:0001530 lipopolysaccharide binding GO Molecular Functions -6.94413823 11 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001776 leukocyte homeostasis GO Biological Processes -5.24665798 8 More
GO:0001780 neutrophil homeostasis GO Biological Processes -3.34912948 3 More
GO:0001786 phosphatidylserine binding GO Molecular Functions -3.87607272 6 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0002200 somatic diversification of immune receptors GO Biological Processes -1.53564628 3 More
GO:0002218 activation of innate immune response GO Biological Processes -2.02855230 4 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002253 activation of immune response GO Biological Processes -3.86084748 14 More
GO:0002262 myeloid cell homeostasis GO Biological Processes -5.37317748 10 More
GO:0002263 cell activation involved in immune response GO Biological Processes -10.3401505 18 More
GO:0002274 myeloid leukocyte activation GO Biological Processes -20.6988408 25 More
GO:0002285 lymphocyte activation involved in immune response GO Biological Processes -7.04246662 12 More
GO:0002366 leukocyte activation involved in immune response GO Biological Processes -10.4998832 18 More
GO:0002407 dendritic cell chemotaxis GO Biological Processes -5.31723275 7 More
GO:0002437 inflammatory response to antigenic stimulus GO Biological Processes -7.96781477 8 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO Biological Processes -1.90591584 3 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002695 negative regulation of leukocyte activation GO Biological Processes -9.84552767 31 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002709 regulation of T cell mediated immunity GO Biological Processes -8.74858930 12 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002833 positive regulation of response to biotic stimulus GO Biological Processes -5.95822718 13 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO Cellular Components -2.09961494 6 More
GO:0006909 phagocytosis GO Biological Processes -7.82039874 17 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0008134 transcription factor binding GO Molecular Functions -5.50998540 50 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010506 regulation of autophagy GO Biological Processes -5.54010569 34 More
GO:0010508 positive regulation of autophagy GO Biological Processes -4.14985165 17 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0016444 somatic cell DNA recombination GO Biological Processes -1.90591584 3 More
GO:0017053 transcription repressor complex GO Cellular Components -4.12949610 12 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0019956 chemokine binding GO Molecular Functions -7.24411974 11 More
GO:0019958 C-X-C chemokine binding GO Molecular Functions -4.66190148 3 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030098 lymphocyte differentiation GO Biological Processes -7.22308617 17 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032653 regulation of interleukin-10 production GO Biological Processes -10.1959901 18 More
GO:0032655 regulation of interleukin-12 production GO Biological Processes -15.9447313 16 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032689 negative regulation of interferon-gamma production GO Biological Processes -6.05054543 11 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0032732 positive regulation of interleukin-1 production GO Biological Processes -14.7376831 16 More
GO:0032733 positive regulation of interleukin-10 production GO Biological Processes -8.60591296 9 More
GO:0032735 positive regulation of interleukin-12 production GO Biological Processes -12.7826256 12 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032757 positive regulation of interleukin-8 production GO Biological Processes -14.6396218 15 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0032872 regulation of stress-activated MAPK cascade GO Biological Processes -11.6818048 20 More
GO:0032874 positive regulation of stress-activated MAPK cascade GO Biological Processes -9.63549885 15 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0034121 regulation of toll-like receptor signaling pathway GO Biological Processes -7.06389205 16 More
GO:0034123 positive regulation of toll-like receptor signaling pathway GO Biological Processes -3.90690001 7 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0036336 dendritic cell migration GO Biological Processes -5.26554247 8 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042104 positive regulation of activated T cell proliferation GO Biological Processes -7.12111476 7 More
GO:0042110 T cell activation GO Biological Processes -7.78997285 18 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043277 apoptotic cell clearance GO Biological Processes -6.75865733 12 More
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -11.0338596 16 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO Biological Processes -5.90313372 12 More
GO:0043388 positive regulation of DNA binding GO Biological Processes -12.0675836 19 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0045088 regulation of innate immune response GO Biological Processes -6.98001665 16 More
GO:0045089 positive regulation of innate immune response GO Biological Processes -3.90916833 9 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045581 negative regulation of T cell differentiation GO Biological Processes -3.22341771 8 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045619 regulation of lymphocyte differentiation GO Biological Processes -8.78322888 17 More
GO:0045620 negative regulation of lymphocyte differentiation GO Biological Processes -5.62617381 12 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0046006 regulation of activated T cell proliferation GO Biological Processes -6.86981007 8 More
GO:0046328 regulation of JNK cascade GO Biological Processes -6.26985667 21 More
GO:0046330 positive regulation of JNK cascade GO Biological Processes -6.26494407 10 More
GO:0046637 regulation of alpha-beta T cell differentiation GO Biological Processes -6.05306731 14 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048872 homeostasis of number of cells GO Biological Processes -12.0072872 22 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051052 regulation of DNA metabolic process GO Biological Processes -4.01973325 42 More
GO:0051054 positive regulation of DNA metabolic process GO Biological Processes -3.76901955 13 More
GO:0051099 positive regulation of binding GO Biological Processes -11.1715489 31 More
GO:0051101 regulation of DNA binding GO Biological Processes -9.69427751 24 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051250 negative regulation of lymphocyte activation GO Biological Processes -7.76846228 25 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding GO Molecular Functions -8.00802452 40 More
GO:0062207 regulation of pattern recognition receptor signaling pathway GO Biological Processes -5.69211704 17 More
GO:0062208 positive regulation of pattern recognition receptor signaling pathway GO Biological Processes -3.35916365 8 More
GO:0070302 regulation of stress-activated protein kinase signaling cascade GO Biological Processes -11.5600448 20 More
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO Biological Processes -9.54226030 15 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071677 positive regulation of mononuclear cell migration GO Biological Processes -15.5919825 16 More
GO:0072341 modified amino acid binding GO Molecular Functions -2.85016161 6 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090025 regulation of monocyte chemotaxis GO Biological Processes -10.2459261 9 More
GO:0090026 positive regulation of monocyte chemotaxis GO Biological Processes -11.8198427 9 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:0140297 DNA-binding transcription factor binding GO Molecular Functions -6.94737226 46 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902106 negative regulation of leukocyte differentiation GO Biological Processes -7.27922558 19 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903131 mononuclear cell differentiation GO Biological Processes -9.35861236 21 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903707 negative regulation of hemopoiesis GO Biological Processes -7.72888419 20 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
GO:1904813 ficolin-1-rich granule lumen GO Cellular Components -6.12299383 11 More
GO:1905564 positive regulation of vascular endothelial cell proliferation GO Biological Processes -12.8410298 14 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000425 regulation of apoptotic cell clearance GO Biological Processes -5.24494293 4 More
GO:2001020 regulation of response to DNA damage stimulus GO Biological Processes -1.68933987 9 More
GO:2001056 positive regulation of cysteine-type endopeptidase activity GO Biological Processes -11.1582582 17 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04140 Autophagy - animal KEGG Pathway -3.52554737 16 More
hsa04217 Necroptosis KEGG Pathway -8.49909048 15 More
Drug-Gene interaction
view
Related drugs: 11 records
Drug name Interaction type Source PMID View
ampicillin NCI 9931456 view
antibiotic NCI 9161031 view
chloramphenicol NCI 9931456 view
cisplatin NCI 94275378968078 view
epigalocatechin gallate NCI 17987129 view
hexamethylenebisacetamide NCI 7741753 view
itraconazole NCI 14639950 view
prednisolone NCI 18447956 view
sodium chloride NCI 17334244 view
urea NCI 3342876 view
volanesorsen sodium NCI 1939057 view
Related studies: 10 records
Molecular factor Omics type Application Objective MI type Reference
high mobility group protein B1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Cirillo P et al. J Card Fail. 2009
high mobility group protein B1 proteomics impaired cardiopulmonary[prognosis (good)] acute myocardial infarction Cirillo P et al. J Card Fail. 2009
high mobility group protein B1 proteomics exercise[other] acute anterior ST elevation myocardial infarction Giallauria F et al. J Card Fail. 2011
high mobility group protein B1 proteomics excellent predictor transmural extent of infarction[other] acute ST elevation myocardial infarction Andrassy M et al. J Intern Med. 2011
high mobility group protein B1 proteomics excellent predictor transmural extent of infarction[other] acute non-ST elevation myocardial infarction Andrassy M et al. J Intern Med. 2011
high mobility group protein B1 proteomics good predictor reduced left ventricular ejection fraction[prognosis (bad)] acute non-ST elevation myocardial infarction Andrassy M et al. J Intern Med. 2011
high mobility group protein B1 proteomics good predictor reduced left ventricular ejection fraction[prognosis (bad)] acute ST elevation myocardial infarction Andrassy M et al. J Intern Med. 2011
high mobility group protein B1 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Sorensen MV et al. JACC Cardiovasc Interv. 2011
high mobility group protein B1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Yao HC et al. Exp Ther Med. 2013
high mobility group protein B1 proteomics cerebral infarction[prognosis (bad)] acute myocardial infarction Chen J et al. Eur Rev Med Pharmacol Sci. 2019
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